The human leukemic fusion protein MLL-AF4 promotes autophagy and cell death in the fat body of Drosophila melanogaster
Aina Louise C Haukeland, Julie Aarmo Johannessen, Nora Rojahn Bråthen, Paul Bergeron, Miriam Formica, Jorrit M. Enserink, Helene Knævelsrud
The paper shows that the human MLL-AF4 fusion protein induces autophagy and cell death in Drosophila fat body cells, contrasting its effect in the hematopoietic system.
bioRxiv · Jul 1, 2026 · PreprintCancer Biology