Jorrit M. Enserink

The paper shows that the human MLL-AF4 fusion protein induces autophagy and cell death in Drosophila fat body cells, contrasting its effect in the hematopoietic system.

The paper shows that transient SUMOylation inhibition in human pre-adipocytes leads to stable beige differentiation when combined with PPARG activation.

This study uses deep learning and time-resolved imaging to map the genetic network controlling autophagy dynamics, revealing a hierarchical control mechanism and new regulatory aspects.

The paper shows SQSTM1/p62 accumulates in BHD kidney tumors due to FLCN loss, but is not required for tumor growth.

This study uses information theory to analyze CRISPR screens and quantifies gene function through geometric measures of selection dynamics and environmental perturbations.

The paper shows that mitotic chromosome condensation resets transcriptional homeostasis by preventing unscheduled gene expression and transcriptional drift in the subsequent interphase.

This study evaluates ex vivo drug sensitivity profiling in AML patients to predict survival and chemotherapy response, showing its robustness in mapping treatment response signatures.

metascreen is an R-package for designing and analyzing drug combination screens, offering modular pipelines, quality control, and integration with synergy-finding tools.

This study identifies the dual role of sumoylation in adipocyte differentiation by regulating gene expression and transcriptional network rewiring through SLAMseq and ChIPseq.

The paper introduces bayesynergy, a Bayesian model for analyzing drug combination experiments, providing uncertainty quantification and handling missing data and uneven concentrations.

This study identifies a RalGPS-Rala-exocyst-Rab11 pathway that regulates Pvr trafficking and signaling in Drosophila lymph glands, maintaining hematopoietic homeostasis.