Tirzepatide Synergizes with Leptin on Weight Loss and Restoring Metabolic Homeostasis in Diet-induced Obesity Model
Xun Sun, Yuexi Yin, Min Song, Brian A. Droz, YANZHU LIN, Kristen N Beaty, Baohua Zhou, Hyun Cheol Roh, Jonathan Matthew Wilson, Paul Cain, Ricardo J. Samms, Patrick L. Sheets, Minrong Ai, Hongxia Ren
This study shows tirzepatide and leptin together enhance weight loss and metabolic homeostasis in diet-induced obesity by improving insulin sensitivity and neuronal signaling.
bioRxiv · Dec 23, 2025 · PreprintNeuroscience