Hyun Cheol Roh

This study shows tirzepatide and leptin together enhance weight loss and metabolic homeostasis in diet-induced obesity by improving insulin sensitivity and neuronal signaling.

This study identifies EphB2 as a driver of MASH liver fibrosis and shows that targeting EphB2 with small molecule inhibitors can reduce fibrosis in mouse models.

This study identifies population-specific transcriptional changes in skeletal muscle myonuclei during pancreatic cancer cachexia, revealing distinct gene activation patterns rather than uniform upregulation of cachexia mediators.

This study uses HaloTag in C. elegans to track intestinal histone turnover and shows protein stability changes during starvation.

This study investigates Ucp1-Cre expression in non-adipose tissues and finds it in epithelial cells during development, but not in adult mammary glands.

This study develops a robust snRNA-seq method to analyze depot-specific adipose tissue remodeling during obesity, identifying distinct adipocyte subpopulations and their functional trajectories.

This study shows that NTS-NTSR2 signaling in white adipocytes regulates food intake by modulating ceramide metabolism and GDF15 production.