Author

Hongxia Ren

Indiana University IndianapolisORCID 0000-0003-2909-4365Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2

Frequent Co-Authors

Jason Michael ConleyiD· 2 shared Val J. WattsiD· 2 shared Alexander JochimiD· 1 shared Baohua ZhouiD· 1 shared Brian A. DroziD· 1 shared Carmella Evans‐MolinaiD· 1 shared Hongmao SuniD· 1 shared Hu Zhu· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersPharmacology & Toxicology

Jason Michael ConleyORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintDec 23, 2025

Tirzepatide Synergizes with Leptin on Weight Loss and Restoring Metabolic Homeostasis in Diet-induced Obesity Model

Xun Sun, Yuexi Yin, Min Song…·Hongxia Ren

This study shows tirzepatide and leptin together enhance weight loss and metabolic homeostasis in diet-induced obesity by improving insulin sensitivity and neuronal signaling.

2 citations

mouseexperimental assay

𝕏 PostBluesky

Pharmacology & ToxicologyEuropean Journal of Medicinal ChemistryPeer-reviewedMay 22, 2025

Discovery of Novel and Selective GPR17 Antagonists as Pharmacological Tools for Developing New Therapeutic Strategies in Diabetes and Obesity

Hu Zhu, Jason Michael Conley, Karavadhi Surendra…·Samarjit Patnaik

The paper identifies two novel GPR17 antagonists through high-throughput screening that selectively inhibit GPR17 signaling and enhance GLP-1 secretion, offering potential for diabetes and obesity treatment.

12 citations

experimental assaydrug response / drug discovery

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Molecular BiologyBiomoleculesPeer-reviewedDec 25, 2024

G protein-coupled receptor 17 inhibits glucagon-like peptide-1 secretion via a Gi/o-dependent mechanism in enteroendocrine cells

Jason Michael Conley, Alexander Jochim, Carmella Evans‐Molina…·Hongxia Ren

This study investigates how GPR17 inhibits GLP-1 secretion in enteroendocrine cells through Gi/o-dependent signaling, using pharmacological and genetic approaches.

9 citations

mouseexperimental assay

𝕏 PostBluesky