Author

Ivo Renkens

Utrecht University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Genetics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:variant calling· 4 Assay:whole-genome sequencing· 4 Approach:experimental assay· 3 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:Hi-C· 1 Research Focus:imputation· 1

Frequent Co-Authors

Wigard P. KloostermaniD· 5 shared Jose Espejo Valle-InclániD· 4 shared Markus J. van RoosmaleniD· 4 shared Christina Stangl· 2 shared Edwin P. J. G. CuppeniD· 2 shared Ewart de BruijniD· 2 shared Jeroen de RidderiD· 2 shared Sam de BlankiD· 2 shared

Activity by Year

2016-2022 · peak 1/yr

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10 top collaborators · 34 mutual co-author links

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5 shared papersGenomics

Wigard P. KloostermanORCID

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Author profile →

6 papers

Recent·Most cited

A multi-platform reference for somatic structural variation detection

Jose Espejo Valle-Inclán, Nicolle J.M. Besselink, Ewart de Bruijn, Daniel Cameron, Jana Ebler, Joachim Kutzera, Stef van Lieshout, Tobias Marschall, Marcel R. Nelen, Andy Wing Chun Pang, Peter Priestley, Ivo Renkens, Margaretha G.M. Roemer, Markus J. van Roosmalen, Aaron M. Wenger, , Edwin P. J. G. Cuppen

The paper compiles a comprehensive reference dataset of true somatic structural variations by analyzing melanoma and normal cell lines with multiple sequencing technologies and experimental validation.

Cell Genomics · Jun 1, 2022Peer-reviewedGenomics

Rapid identification of genomic structural variations with nanopore sequencing enables blood-based cancer monitoring

Jose Espejo Valle-Inclán, Christina Stangl, Anouk C. de Jong, Lisanne F. van Dessel, Markus J. van Roosmalen, Jean Helmijr, Ivo Renkens, Roel Janssen, Sam de Blank, Chris J. de Witte, John W.M. Martens, Maurice P.H.M. Jansen, Martijn P. Lolkema, Wigard P. Kloosterman

SHARC rapidly identifies somatic genomic structural variations from nanopore sequencing for blood-based cancer monitoring, detecting ten SVs per sample and enabling treatment response tracking in metastatic prostate cancer.

Genome Medicine · May 18, 2021Peer-reviewedGenetic & Genomic Medicine

Partner-independent fusion gene detection by multiplexed CRISPR/Cas9 enrichment and long-read Nanopore sequencing

Christina Stangl, Sam de Blank, Ivo Renkens, Liset Westera, Tamara C. A. I. Verbeek, Jose Espejo Valle-Inclán, Rocío Chamorro González, Anton George Henssen, Markus J. van Roosmalen, Ronald W. Stam, Emile E. Voest, Wigard P. Kloosterman, Gijs W van Haaften, Glen R. Monroe

This paper introduces FUDGE, a method for detecting fusion genes using CRISPR/Cas9 enrichment and long-read sequencing, achieving high sensitivity and specificity across various cancer types.

Nature Communications · Jun 5, 2020Peer-reviewedGenomics

Locus-Specific Enhancer Hubs And Architectural Loop Collisions Uncovered From Single Allele DNA Topologies

Amin Allahyar, Carlo Vermeulen, Britta A. M. Bouwman, Peter H.L. Krijger, Marjon J.A.M. Verstegen, Geert Geeven, Melissa van Kranenburg, Mark Pieterse, Roy Straver, Judith H.I. Haarhuis, Kees Jalink, Hans Teunissen, Ivo Renkens, Wigard P. Kloosterman, Benjamin D. Rowland, , Wouter L. de Laat

The paper introduces a new 3C method, MC-4C, to study multi-way DNA conformations and reveals cooperative and competitive chromatin interactions, including enhancer hubs and loop collisions.

Nature Genetics · Jul 6, 2018Peer-reviewedGenetics

Mapping And Phasing Of Structural Variation In Patient Genomes Using Nanopore Sequencing

Mircea Cretu-Stancu, Markus J. van Roosmalen, Ivo Renkens, Marleen M. Nieboer, Sjors Middelkamp, Joep de Ligt, Giulia Pregno, Daniela Francesca Giachino, Giorgia Mandrile, Jose Espejo Valle-Inclán, Jerome Korzelius, Ewart de Bruijn, Edwin P. J. G. Cuppen, Michael E. Talkowski, Tobias Marschall, , Wigard P. Kloosterman

This study uses nanopore sequencing to detect and phase structural variants in patient genomes, identifying novel variants missed by short-read sequencing.

Nature Communications · Oct 31, 2017Peer-reviewedGenomics

A high-quality reference panel reveals the complexity and distribution of structural genome changes in a human population

Jayne Y. Hehir-Kwa, Tobias Marschall, Wigard P. Kloosterman, Laurent C. Francioli, Jasmijn A. Baaijens, Louis J. Dijkstra, Abdel Abdellaoui, Vyacheslav Koval, Djie Tjwan Thung, René Wardenaar, Ivo Renkens, Bradley P. Coe, Patrick Deelen, Joep de Ligt, Eric-Wubbo Lameijer, , Victor Guryev

This study creates a high-quality reference panel of structural variants from 769 Dutch individuals, revealing new variants and their linkage to known SNPs, improving imputation accuracy for genome-wide association studies.

bioRxiv · Jul 2, 2016 · PreprintGenetics