Paul E. Klotman

Atorvastatin suppresses cardiac fibrosis and dysfunction induced by HIV and certain antiretroviral drugs in mice by blocking platelet TGFβ1

This study shows that atorvastatin reduces HIV and ART-induced cardiac fibrosis and dysfunction in mice by blocking platelet TGFβ1, independent of cholesterol changes.

Reference plasmid pHXB2_D is an HIV-1 molecular clone that exhibits identical LTRs and a single integration site indicative of an HIV provirus

The paper compares long-read nanopore DNA sequencing with short-read sequencing for full-length HIV-1 provirus analysis, finding full coverage and variants in a reference plasmid.