Atorvastatin suppresses cardiac fibrosis and dysfunction induced by HIV and certain antiretroviral drugs in mice by blocking platelet TGFβ1
Kumar Subramani, Denys Babii, Brienne Cole, Tanveer Afzal, Thamizhiniyan Venkatesan, Trevor Word, Sandra Gostynska, Sixia Chen, Kar‐Ming Fung, Ali Danesh, Itzayana G. Miller, Paul E. Klotman, Richard Brad Jones, Jeffrey C. Laurence, Jasimuddin Ahamed
This study shows that atorvastatin reduces HIV and ART-induced cardiac fibrosis and dysfunction in mice by blocking platelet TGFβ1, independent of cholesterol changes.
bioRxiv · Sep 17, 2025 · PreprintBiochemistry