Ali Danesh

This study characterizes HIV reservoir clones and shows they can be culled by sustained CTL pressure, with some displaying intrinsic resistance linked to low oxidative stress.

This study investigates how HIV-1 integration sites influence viral latency and clonal expansion in human memory CD4+ T cells engrafted into mice.

The paper introduces HIV SMRTcap, a method for characterizing HIV-1 reservoirs by identifying integration sites and proviral integrity using long-read sequencing, and validates its performance across subtypes and tissue samples.

This study shows HIV increases sialoglycan expression to engage Siglecs on myeloid cells, promoting immune evasion, and demonstrates that disrupting these interactions enhances immune killing of infected cells.

This study shows that atorvastatin reduces HIV and ART-induced cardiac fibrosis and dysfunction in mice by blocking platelet TGFβ1, independent of cholesterol changes.

The paper shows that tazemetostat reduces HIV reservoirs and improves CD8+ T-cell function by increasing MHC-I expression and promoting anti-HIV immune responses.