The 5α-reductase inhibitor finasteride reduces opioid self-administration
Gabriel D. Bossé, Roberto Cadeddu, Gabriele Floris, Ryan D. Farero, Eva Vigato, Suhjung Janet Lee, Tejia Zhang, Nilesh W. Gaikwad, Kristen A. Keefe, Paul E.M. Philips, Marco Bortolato, Randall Theodore Peterson
This study shows finasteride reduces opioid self-administration in zebrafish and rats without affecting locomotion or feeding, and suggests steroidogenic pathways as potential targets for OUD treatment.
bioRxiv · Sep 15, 2020 · PreprintNeuroscience