Enhancing cGMP signaling with psilocybin reduces head twitch and restructures the synaptic proteome while maintaining antidepressant response
Gabriele Floris, Sarah J. Jefferson, Jocelyne A. Rondeau…·Alfred P. Kaye
This study combines psilocybin with a PDE9 inhibitor to reduce head-twitch response and alter synaptic proteome while preserving antidepressant effects.