Marco Bortolato

This study identifies pervasive transcriptional remodeling in the dorsolateral prefrontal cortex of individuals with Tourette disorder, highlighting stress-related gene activation in multiple cell types.

This study shows sleep deprivation impairs information processing in the prefrontal cortex by disrupting chloride homeostasis through KCC2 reduction and BDNF-TrkB signaling, which can be mitigated by bumetanide or AP synthesis blockade.

This study shows that elevated prefrontal 5-HT2A receptors contribute to tic development in TS and that pimavanserin reduces tic-like behaviors and aggression in mouse models.

This study identifies 5R2 as a key mediator of male-specific acute stress response in the prefrontal cortex through increased expression and AP synthesis under stress.

The paper investigates how Celsr3 mutations affect tic-like behaviors in mice by examining striatal dopamine receptor alterations.

The paper introduces a naive Bayes classifier to automate grooming behavior analysis in mice using force-plate actometry, achieving high accuracy and demonstrating its utility in tic disorder models.

This study shows acute stress impairs sensorimotor gating by increasing allopregnanolone in the prefrontal cortex, which can be reversed by blocking allopregnanolone.

The paper shows that a gene-environment interaction involving MAO A gene variants and early life stress increases vulnerability to cocaine sensitization through endocannabinoid-dependent changes in GABAergic transmission in dopamine neurons.

The paper examines sex-differentiated genetic effects across neuropsychiatric and behavioral traits using GWAS summary statistics and finds small, polygenic sex differences with enriched neuron-related genes.

This study shows finasteride reduces opioid self-administration in zebrafish and rats without affecting locomotion or feeding, and suggests steroidogenic pathways as potential targets for OUD treatment.