Author

Paul Hess

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:long-read sequencing· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Anuja SatheiD· 2 shared Hanlee P. JiiD· 2 shared Nancy Ruonan ZhangiD· 2 shared Billy T. LauiD· 1 shared Chi-Yun WuiD· 1 shared Emma Elizabeth FurthiD· 1 shared Heon Seok KimiD· 1 shared Jenea I. AdamsiD· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Anuja SatheORCID

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Author profile →

2 papers

Recent·Most cited

Single cell and spatial alternative splicing analysis with long read sequencing

Yuntian Fu, Heon Seok Kim, Jenea I. Adams, Susan M. Grimes, Sijia Huang, Billy T. Lau, Anuja Sathe, Paul Hess, Hanlee P. Ji, Nancy Ruonan Zhang

The paper develops Longcell, a statistical framework for accurate isoform quantification in single cell and spatial long-read sequencing data, revealing intra-cell splicing heterogeneity and validating regulatory targets.

bioRxiv · Feb 23, 2023 · PreprintBioinformatics

Niche differential gene expression analysis in spatial transcriptomics data identifies context-dependent cell-cell interactions

Kaishu Mason, Anuja Sathe, Paul Hess, Jiazhen Rong, Chi-Yun Wu, Emma Elizabeth Furth, Hanlee P. Ji, Nancy Ruonan Zhang

The paper introduces niche-differential expression analysis to identify context-dependent cell-cell interactions in spatial transcriptomics data and applies it to colorectal cancer metastases.

bioRxiv · Jan 3, 2023 · PreprintBioinformatics