Emma Elizabeth Furth

Pharmacological reduction of neutrophil infiltration reduces Clostridioides difficile infection severity

This study shows that misoprostol reduces C. difficile infection severity by decreasing neutrophil infiltration and G-CSF levels, highlighting innate immune modulation as a therapeutic strategy.

Designing smart spatial omics experiments with S2Omics

S2Omics automatically selects regions of interest from histology images to maximize molecular information content in spatial omics experiments, improving reproducibility and downstream biological discovery.

E2f coordinates the proliferation and transdifferentiation of a Sox9+bile duct cell to initiate hepatocellular carcinoma

This study shows that E2f activation in Sox9+ bile duct cells drives proliferation and transdifferentiation into hepatocytes, initiating hepatocellular carcinoma.

Mitochondrial clone tracing within spatially intact human tissues

SUMMIT traces mitochondrial mutations in human tissues to identify spatially localized clones and their transcriptomic profiles.

Long Noncoding RNAs Preserve Pancreatic Cancer Identity and Resist Cell Fate Conversion

This study identifies long noncoding RNAs as key regulators of pancreatic cancer identity and resistance to reprogramming.

Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity

This study shows that mitochondrial Ca2+ uptake via MCU promotes pancreatic cancer growth and metastasis by enhancing epithelial plasticity through EMT.

A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer

This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.

Multimetric MRI Captures Early Response and Acquired Resistance of Pancreatic Cancer to KRAS Inhibitor Therapy

Diverticular disease genome-wide association meta-analysis identifies 257 novel loci, implicates structure and motility

This study identifies 257 novel genetic loci associated with diverticular disease through a large GWAS, linking them to connective tissue and colonic motility mechanisms.

Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease

This study shows that diet can significantly affect survival in a mouse model of Hirschsprung disease by altering gut microbes, metabolites, and epithelial gene expression.

Effect of Stroma-directed Drugs in Combination with Chemotherapy Against Pancreatic Cancer- a Preclinical Study

This study compares chemotherapy with and without stroma-directed drugs in a mouse model of pancreatic cancer, finding enhanced tumor growth inhibition and changes in tumor microenvironment.

Niche differential gene expression analysis in spatial transcriptomics data identifies context-dependent cell-cell interactions

The paper introduces niche-differential expression analysis to identify context-dependent cell-cell interactions in spatial transcriptomics data and applies it to colorectal cancer metastases.