Genetically edited human placental organoids cast new light on the role of ACE2 in placental development
Anya L. Arthurs, Bianca Dietrich, Martin Knöfler, Caleb Lushington, Paul Q. Thomas, Fatwa Adikusuma, Jessica M. Williamson, Susan Babikha, Tyla Damhuis, Tanja Jankovic‐Karasoulos, M. Smith, Kirsty G. Pringle, Claire Trelford Roberts
This study uses gene-edited placental organoids to show that ACE2 knockout causes delayed growth and increased cell death, while the ACE2 rs2074192 TT genotype increases ACE2 expression but reduces enzyme activity.
Cell Death and Disease · Feb 7, 2025Peer-reviewedMolecular Biology