Martin Knöfler

This study uses gene-edited placental organoids to show that ACE2 knockout causes delayed growth and increased cell death, while the ACE2 rs2074192 TT genotype increases ACE2 expression but reduces enzyme activity.

This study shows that NOTCH3 signaling regulates human trophoblast stem cell expansion and differentiation, with implications for placental development and pregnancy disorders.

The paper identifies a disrupted trophoblast transition in preeclampsia, linking placental pathology to maternal syndrome through multi-omics profiling and in vitro analyses.

This study identifies WWTR1 as a master regulator of human trophoblast progenitor self-renewal and differentiation, showing its role in promoting EVT differentiation and preventing STB fate.

This study shows MSX2 regulates syncytiotrophoblast fate in human trophoblast stem cells by directly controlling gene expression and interacting with the SWI/SNF complex.