Neurovascular coupling preserved in a chronic mouse model of Alzheimers disease: Methodology is critical.
Paul S Sharp, Kamar E Ameen-Ali, Luke Boorman, Sam Harris, Stephen B. Wharton, Clare Howarth, Osman Shabir, Peter Redgrave, Jason Berwick
The paper shows that neurovascular coupling is preserved in J20-AD mice under chronic anesthesia but not during acute procedures, emphasizing the impact of experimental methodology.
Journal of Cerebral Blood Flow & Metabolism · Nov 23, 2019Peer-reviewedNeuroscience