Luke W. Boorman

Disassociating cerebral vasomotion from low frequency spontaneous neurovascular coupling

This study investigates cerebral vasomotion in anaesthetised rats, finding it driven by the arterial tree and largely independent of neural activity.

Nitric oxide is not responsible for the initial sensory-induced neurovascular coupling response in mouse cortex.

The paper investigates the role of nitric oxide in neurovascular coupling responses in mouse cortex, finding that it mediates responses from nNOS-expressing interneurons but not sensory stimulation.

Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo: Implications for theragnostics

This study shows that changes in cortical temperature modulate neurovascular coupling, with low temperatures reducing oxygen delivery and high temperatures causing vascular oscillations.

The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice

This study shows that locomotion during awake imaging alters sensory-evoked haemodynamic responses in mice, emphasizing the need to monitor movement to avoid confounding results.

Enhanced Cerebral Blood Volume under Normobaric Hyperoxia in the J20-hAPP Mouse Model of Alzheimer's Disease

The paper investigates neurovascular coupling in J20-hAPP mice under normobaric hyperoxia, finding enhanced cerebral blood volume and potential therapeutic implications for Alzheimer's disease.

Neurovascular coupling preserved in a chronic mouse model of Alzheimers disease: Methodology is critical.

The paper shows that neurovascular coupling is preserved in J20-AD mice under chronic anesthesia but not during acute procedures, emphasizing the impact of experimental methodology.

Key aspects of neurovascular control mediated by specific populations of inhibitory cortical interneurons

The paper investigates how specific inhibitory cortical interneurons influence neurovascular coupling through optogenetic activation in mice, revealing distinct hemodynamic effects based on interneuron type.

Physiological and pathological brain activation in the anesthetized rat produces hemodynamic-dependent cortical temperature increases that can confound the BOLD fMRI signal.

The paper shows that temperature increases in anesthetized rat brains during activation can confound BOLD fMRI signals by being linked to hemoglobin changes.

Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation.

The paper investigates how seizure epicenter depth and laminar synchrony affect tissue oxygenation during ictal initiation in a rat model, revealing layer-dependent hypoxia and hyperoxia patterns.