Jason Berwick

This study investigates cerebral vasomotion in anaesthetised rats, finding it driven by the arterial tree and largely independent of neural activity.

The paper investigates the role of nitric oxide in neurovascular coupling responses in mouse cortex, finding that it mediates responses from nNOS-expressing interneurons but not sensory stimulation.

This study examines vascular function and cognitive performance in mouse models of Alzheimer's disease, atherosclerosis, and their combination, finding hemodynamic deficits in atherosclerosis mice and no differences in amyloid or plaque burden in mixed disease models.

The paper examines locomotion-induced hemodynamic responses in different vascular compartments of the whisker barrel cortex in mice, finding an early HbT decrease in draining and meningeal veins.

This study examines how cholinergic drugs affect neurovascular coupling and neuroimaging signals in rats, showing altered coupling and response magnitudes with agonist and antagonist treatments.

This study shows that changes in cortical temperature modulate neurovascular coupling, with low temperatures reducing oxygen delivery and high temperatures causing vascular oscillations.

This study shows that locomotion during awake imaging alters sensory-evoked haemodynamic responses in mice, emphasizing the need to monitor movement to avoid confounding results.

This study assesses neurovascular coupling and cortical spreading depression in models of atherosclerosis and Alzheimer's disease, finding exacerbated neurovascular decline and increased amyloid-beta plaques in comorbid conditions.

This paper validates layer-specific VASO fMRI across species by comparing it to optical imaging and MION contrast enhanced fMRI in rats and humans, confirming its reliability for estimating layer-specific CBV changes.

The paper investigates neurovascular coupling in J20-hAPP mice under normobaric hyperoxia, finding enhanced cerebral blood volume and potential therapeutic implications for Alzheimer's disease.

This study investigates how acute systemic inflammation affects neurovascular unit function and cerebrovascular dynamics in rats, showing altered haemodynamics and NVU pathology.

This study shows that experimental atherosclerosis in mice leads to reduced cortical hemodynamics and neural activity, associated with neuroinflammation and neuronal loss.

The paper shows that neurovascular coupling is preserved in J20-AD mice under chronic anesthesia but not during acute procedures, emphasizing the impact of experimental methodology.

The paper investigates how specific inhibitory cortical interneurons influence neurovascular coupling through optogenetic activation in mice, revealing distinct hemodynamic effects based on interneuron type.

This study examines recognition memory and glial pathology in hAPP-J20 mice, finding early memory impairment precedes Aβ deposition and glial activation.

The paper shows that temperature increases in anesthetized rat brains during activation can confound BOLD fMRI signals by being linked to hemoglobin changes.

The paper investigates how seizure epicenter depth and laminar synchrony affect tissue oxygenation during ictal initiation in a rat model, revealing layer-dependent hypoxia and hyperoxia patterns.