Sam Harris

This study shows that oligodendrocytes produce amyloid beta in Alzheimer's Disease and that suppressing this production improves brain pathology and neuronal function.

The paper generates C9orf72 DPR knock-in mice and identifies an extracellular matrix signature in C9ALS/FTD that is conserved across species and protected by TGF-β1 and COL6A1.

This study shows that changes in cortical temperature modulate neurovascular coupling, with low temperatures reducing oxygen delivery and high temperatures causing vascular oscillations.

The paper shows that neurovascular coupling is preserved in J20-AD mice under chronic anesthesia but not during acute procedures, emphasizing the impact of experimental methodology.

The paper shows that temperature increases in anesthetized rat brains during activation can confound BOLD fMRI signals by being linked to hemoglobin changes.

The paper investigates how seizure epicenter depth and laminar synchrony affect tissue oxygenation during ictal initiation in a rat model, revealing layer-dependent hypoxia and hyperoxia patterns.