The embryo-derived protein PDI is highly conserved among placental mammals and alters the function of the endometrium in species with different implantation strategies.
Haidee Tinning, Alysha S Taylor, Dapeng Wang, Anna L. Pullinger, Georgios Oikonomou, Miguel Abraham Velazquez, Paul Thompson, Achim Treumann, Peter T Ruane, Mary J. O’Connell, Niamh Forde
The paper shows that PDI, a conserved protein, alters endometrial function in species with different implantation strategies by modifying transcriptomes and secretomes.
bioRxiv · May 2, 2024 · PreprintDevelopmental Biology