Haidee Tinning

Bovine endometrial organoids: A new tool to study conceptus-maternal interactions in mammals

The paper develops a bovine endometrial organoid model to study hormone responsiveness and conceptus-maternal interactions, identifying differentially expressed genes and biological processes.

Mammal placental phenotypes are predictable from microRNA repertoires.

The paper shows that placental phenotypes in mammals can be predicted from miRNA repertoires with high accuracy, revealing constrained genetic pathways for convergent evolution.

An evolutionarily conserved microRNA, miR-185, regulates key pathways that may contribute to implantation failure.

This study shows miR-185-5p regulates pathways linked to implantation failure by altering protein expression and CNP family gene activity in endometrial cells.

A 3D endometrium-on-a-chip reveals the role of conceptus-derived factors CAPG and PDI in conceptus-endometrial communication

This paper develops a 3D bovine endometrium-on-a-chip system to study conceptus-derived factors CAPG and PDI's effects on endometrial transcriptome and secretome.

Biosensor capability of the endometrium is mediated in part, by altered miRNA cargo from conceptus-derived extracellular vesicles.

The paper investigates how endometrial biosensor capability is influenced by miRNA cargo in conceptus-derived extracellular vesicles during peri-implantation, showing differential miRNA effects on endometrial gene expression.

The embryo-derived protein PDI is highly conserved among placental mammals and alters the function of the endometrium in species with different implantation strategies.

The paper shows that PDI, a conserved protein, alters endometrial function in species with different implantation strategies by modifying transcriptomes and secretomes.

Differences in binding preferences for XIST partners are observed in mammals with different early pregnancy morphologies

The paper examines XIST RNA-protein interactions across mammals with different early pregnancy morphologies, finding conserved binding partners but species-specific binding preferences.

Sex-bias in utero alters ovarian reserve but not uterine capacity in female offspring

This study investigates the effects of in-utero sex bias on reproductive traits in female pigs, finding that birth weight has a greater impact than litter sex ratio on ovarian reserve and uterine development.

Endometrium-on-a-chip reveals the endometrial transcriptome, and protein content of secretome are altered by changes in circulating concentrations of insulin and glucose in vitro.

The paper uses an endometrium-on-a-chip system to show that changes in glucose and insulin concentrations alter the transcriptome and secretome of endometrial cells in vitro.