Peter T Ruane

This paper develops a microfluidic platform integrating fallopian tube organoids to study epithelial function and disease, showing viable cultures and comparable cell health to intact organoids.

The paper develops a bovine endometrial organoid model to study hormone responsiveness and conceptus-maternal interactions, identifying differentially expressed genes and biological processes.

The paper uses single-cell transcriptomic data to identify cellular specialization, differentiation trajectories, and gene network associations with ectopic pregnancy in fallopian tube epithelium.

The paper shows that PDI, a conserved protein, alters endometrial function in species with different implantation strategies by modifying transcriptomes and secretomes.

The paper models human embryo implantation using blastocysts and endometrial epithelial cells, showing EEC-induced syncytiotrophoblast differentiation as the mechanism for embryonic invasion.