GenomicsNucleic Acids ResearchPeer-reviewed
Loss of SUMOylation drives aberrant PRC1 clustering and 3D genome rewiring independent of H3K27me3
Nazli Akilli, Paul-Swann Puel, Marco Di Stefano…·Giacomo Cavalli
This study shows that SUMOylation loss in Drosophila disrupts PRC1 condensates, causing 3D genome rewiring and gene misregulation without affecting H3K27me3 levels.
DOI 10.1093/nar/gkag851