Giacomo Cavalli

This study identifies a scaffolding element that drives chromatin rewiring during differentiation by modulating 3D structure and transcription.

This study shows that SUMOylation loss in Drosophila disrupts PRC1 condensates, causing 3D genome rewiring and gene misregulation without affecting H3K27me3 levels.

The paper shows that GAF and a combinatorial code of looping factors determine PRE-specific chromatin looping, independent of PH and H3K27me3.

This study shows that interchromosomal contacts between regulatory regions can establish stable transgenerational epigenetic inheritance in Drosophila through chromatin interactions mediated by GAGA-factor and Pleiohomeotic.

The paper shows that transient histone deacetylase inhibition in mESCs induces cellular memory of gene expression and 3D genome folding, with genome architecture maintaining perturbed conformations.

The paper uses multiplexed chromatin imaging to show that Drosophila Polycomb genes predominantly form pairwise long-range interactions rather than clustering during development.

The paper shows that transient loss of Polycomb components in Drosophila induces an irreversible cancer fate through epigenetic reprogramming without driver mutations.

The paper investigates the relationship between regulatory information density and evolutionary constraint in non-coding DNA of Drosophila, finding that dense regulatory regions contribute significantly to constraint.

The paper investigates how environmental factors disrupt epigenetic memory, leading to organ transformation in Drosophila through altered protein integrity and histone modifications.

The paper identifies hundreds of Drosophila chromatin insulator elements dependent on Cp190 and CTCF by analyzing genomic contacts, transcriptomes, and protein binding in deficient cells.

The paper shows that divergent gene expression within TADs is resolved through TAD restructuring and DNA methylation, not enhancer-promoter compatibility or position.

The paper investigates how enhancers regulate duplicated genes in Drosophila, showing differential activity and evolutionary conservation between tissue-specific and pleiotropic enhancers.

The paper investigates the 3D organization of Drosophila melanogaster pericentromeric heterochromatin domains and their spatial interactions with euchromatic regions enriched in H3K9me2/3 marks.

MuGVRE provides a cloud-based infrastructure for 3D/4D genomics analysis, supporting both high-computational and high-throughput applications.

This study shows that PRC1 compacts Hox gene clusters during early Drosophila embryogenesis to prevent transcriptional derepression later in development.

The paper investigates how the Drosophila dosage compensation complex activates X chromosome genes through chromosome looping within the active compartment.