Fernando Muzzopappa

This study shows that SUMOylation loss in Drosophila disrupts PRC1 condensates, causing 3D genome rewiring and gene misregulation without affecting H3K27me3 levels.

The paper investigates how heterochromatin proteins form barrier compartments in cells, showing differences between proteins, cell types, and compartments, and proposes a model based on protein accumulation and competition.

This study shows that HP1 dimerization drives H3K9me chromatin condensation and segregation, while LLPS stabilizes foci, and reveals a decoupling between heterochromatin and transcriptional regulation.

This study shows TRIP12's intrinsically disordered region drives chromatin condensate formation, disrupting DNA damage response and genome accessibility.