Marco Di Stefano

This study identifies a scaffolding element that drives chromatin rewiring during differentiation by modulating 3D structure and transcription.

This study shows that SUMOylation loss in Drosophila disrupts PRC1 condensates, causing 3D genome rewiring and gene misregulation without affecting H3K27me3 levels.

The paper shows that GAF and a combinatorial code of looping factors determine PRE-specific chromatin looping, independent of PH and H3K27me3.

The paper shows that transient histone deacetylase inhibition in mESCs induces cellular memory of gene expression and 3D genome folding, with genome architecture maintaining perturbed conformations.

The paper shows that transient loss of Polycomb components in Drosophila induces an irreversible cancer fate through epigenetic reprogramming without driver mutations.

This study examines 3D genome architecture changes during B cell differentiation and in B cell neoplasias using Hi-C and multi-omic data, revealing dynamic compartment shifts and tumor-specific chromatin reorganization.

This paper introduces a method to reconstruct 3D chromatin organization from sparse 3C-based data, achieving reliable results with as little as 2-3% of the interaction matrix.

TADpole identifies hierarchical chromatin domains in Hi-C data, revealing significant structural differences between wild-type and mutant mouse strains.

The paper introduces TADdyn, a tool that simulates chromatin structural rearrangements during cell reprogramming using time-course 3C data and molecular dynamics, revealing a hit-and-stick mechanism for transcriptional stabilization.