Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense
Eva Horáková, Laurence Lecordier, Paula Cunha, Roman Sobotka, Piya Changmai, Catharina J. M. Langedijk, Jan Van Den Abbeele, Benoît Vanhollebeke, Julius Lukeš
This study identifies heme-deficient metabolism and impaired cellular differentiation as evolutionary trade-offs for human infectivity in Trypanosoma brucei gambiense due to HpHbR inactivation.
Nature Communications · Nov 18, 2022Peer-reviewedDevelopmental Biology