Aβ promotes amyloidogenic processing of APP through a Go/Gβγ signaling
Magdalena Antonino, Paula Marmo, Carlos Leandro Freites, Gonzalo Quassollo, M. Florencia Sánchez, Alfredo Lorenzo, Elena Anahí Bignante
This study identifies a feed-forward mechanism where Aβ promotes APP processing via Go/Gβγ signaling, enhancing Aβ production and suggesting gallein as a potential therapeutic target.
bioRxiv · Mar 10, 2021 · PreprintNeuroscience