NeurosciencebioRxivPreprint
Aβ promotes amyloidogenic processing of APP through a Go/Gβγ signaling
Magdalena Antonino, Paula Marmo, Carlos Leandro Freites…·Elena Anahí Bignante
This study identifies a feed-forward mechanism where Aβ promotes APP processing via Go/Gβγ signaling, enhancing Aβ production and suggesting gallein as a potential therapeutic target.
DOI 10.1101/2021.03.10.434768