Experimental and mathematical models reveal that AMPK modulates circadian clock gene expression and period through NAD+-dependent regulation of Bmal1
Alan Vandenberghe, Pauline Delpierre, Raoul Torero Ibad, Pierre Leclerc, Anthony Treizebre, Alexandre Berthier, Laurent Héliot, Hélène Duez, Bart Staels, Philippe Lefèbvre, Alessandro Furlan, Marc Lefranc
The paper shows that AMPK modulates circadian clock period and Bmal1 expression through NAD+-dependent mechanisms, validated by experiments and mathematical modeling.
bioRxiv · Sep 30, 2026 · PreprintCell Biology