Author

Marc Lefranc

Centre National de la Recherche ScientifiqueORCID 0000-0003-2563-7967Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Pauline Delpierre· 2 shared Alan VandenbergheiD· 1 shared Alessandro FurlaniD· 1 shared Alexandre BerthieriD· 1 shared Anthony TreizebreiD· 1 shared Bart StaelsiD· 1 shared Hélène DueziD· 1 shared Laurent Héliot· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Pauline Delpierre

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 30, 2026

Experimental and mathematical models reveal that AMPK modulates circadian clock gene expression and period through NAD+-dependent regulation of Bmal1

Alan Vandenberghe, Pauline Delpierre, Raoul Torero Ibad…·Marc Lefranc

The paper shows that AMPK modulates circadian clock period and Bmal1 expression through NAD+-dependent mechanisms, validated by experiments and mathematical modeling.

DOI 10.64898/2026.09.29.755034

humanstatistical model

𝕏 PostBluesky

Systems BiologyBiophysical JournalPeer-reviewedJan 19, 2026

A minimal activator-inhibitor-repressor model of the hepatic circadian clock

Pauline Delpierre, Marc Lefranc

The paper develops a minimal three-gene model of the hepatic circadian clock in mice that accurately captures temporal expression profiles and predicts synchronizing mechanisms.

DOI 10.1016/j.bpj.2026.01.024

mousestatistical model

𝕏 PostBluesky