Direct effects on gene transcription revealed by global and CRISPR-targeted oxidative DNA damage
Luana Cintori, Catherine Chailleux, Pauline Maller, Anne Marie Di Guilmi, Capucine Siberchicot, Tomas Caetano, Emma Lehir, Virginie Jouffret, Céline Reyes, Marion Aguirrebengoa, Anna Campalans, Valérie Bergoglio, Didier Trouche, Yvan Canitrot
The paper shows oxidative DNA damage directly affects gene transcription through repair-dependent mechanisms using RNA-Seq, ChIP-seq, and chemogenetic approaches.
bioRxiv · Oct 27, 2026 · PreprintGenomics