Author

Didier Trouche

Centre National de la Recherche ScientifiqueORCID 0000-0003-1398-6481Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:ChIP-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Estelle NicolasiD· 2 shared Julien OuvrardiD· 2 shared Lisa MuniziD· 2 shared Marion AguirrebengoaiD· 2 shared Anna CampalansiD· 1 shared Anne Marie Di GuilmiiD· 1 shared Capucine Siberchicot· 1 shared Catherine ChailleuxiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Estelle NicolasORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 27, 2026

Direct effects on gene transcription revealed by global and CRISPR-targeted oxidative DNA damage

Luana Cintori, Catherine Chailleux, Pauline Maller…·Yvan Canitrot

The paper shows oxidative DNA damage directly affects gene transcription through repair-dependent mechanisms using RNA-Seq, ChIP-seq, and chemogenetic approaches.

DOI 10.64898/2026.10.26.761859

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintMay 11, 2022

siRNAs targeting a chromatin-associated RNA induce its transcriptional silencing in human cells

Julien Ouvrard, Lisa Muniz, Estelle Nicolas, Didier Trouche

This study shows that siRNAs targeting a chromatin-associated RNA can induce its transcriptional silencing in human cells through cis-specific base pairing.

DOI 10.1101/2022.05.11.491477

humanDNA methylation

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Molecular BiologyRNA BiologyPeer-reviewedAug 30, 2020

Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence

Lisa Muniz, Sandra Lazorthes, Maxime Delmas…·Estelle Nicolas

The paper shows that circular ANRIL isoforms switch from repressing to activating p15/CDKN2B expression during RAF1-induced senescence by altering Polycomb protein interactions.

23 citations

humanlong-read sequencing

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