Tuning Mitotic Recombination with Patterned DNA Nicks for Precision Mosaic Analysis
Yifan Shen, Ann T Yeung, Bei Wang, Chun-Ting Yeh, Payton Ditchfield, Elizabeth Korn, Chun Han
This paper introduces nickase-based MAGIC as a safer alternative to DSB-based CRISPR/Cas9 for generating genetic mosaics in Drosophila, showing that single-strand nicks can induce recombination with tunable efficiency.
Proceedings of the National Academy of Sciences · May 27, 2026Peer-reviewedDevelopmental Biology