Xinchen Chen

The paper introduces a genome-wide gRNA-marker kit for MAGIC in Drosophila, enabling clonal analysis of previously inaccessible genetic elements and tissues.

This paper develops a toolkit using AcrIIA4 to suppress, subtract, and segregate Cas9 activity in Drosophila for more precise CRISPR applications.

This study shows that the Drosophila ABCA protein Eato regulates neurodegeneration by opposing roles in neurons and phagocytes, affecting phagocytosis through suppression of phosphatidylserine signals.

The paper develops a CRISPR toolkit for tissue-specific gene knockout in Drosophila motor neurons, muscles, and glial cells, revealing ESCRT's role in NMJ extracellular vesicle formation.

This study identifies Orion as a bridging molecule that connects phosphatidylserine and Draper in Drosophila phagocytosis of degenerating neurons, revealing a conserved mechanism.