Analgesic actions of Intrathecal NaV 1.7 antisense in rats: loss of antagonist channel binding, message depletion, and neuraxial distribution of oligonucleotide
Kauê Franco Malange, Júlia Borges Paes Lemes, Briana Noble, Yuvicza Anchondo, Carlos Eduardo Morado-Urbina, Saee Jadhav, Sara Anna Dochnal, Chiraag Kambalimath, Pedro Álvarez, Bethany Fitzsimmons, Curt Mazur, Holly B. Kordasiewicz, Kim Doré, Hien Tran Zhao, Tony L. Yaksh
This study evaluates the analgesic effects of intrathecal NaV 1.7 antisense oligonucleotides in rats, showing reduced channel binding and pain behaviors with concentration-dependent knock-down of Scn9a mRNA.
bioRxiv · May 19, 2025 · PreprintNeuroscience