Kim Doré

Excessive cholesterol accumulation in microglia increases neuronal synaptic vulnerability to amyloid-beta

This study shows that microglial cholesterol accumulation worsens neuronal synaptic vulnerability to amyloid-beta in Alzheimer's disease.

ESCRT-0 regulates AMPA receptor currents and Ca2+- dependent signaling

This study shows that Hrs, an ESCRT-0 protein, modulates AMPA receptor currents and Ca2+-dependent signaling by sensing and responding to neuronal activity at synapses.

Human dorsal root ganglia neuronal cell line to study nociceptive signaling: a new pipeline for pain therapy.

The paper develops a human-derived in vitro model of nociceptive signaling using HD10.6 cells to study pain mechanisms and drug responses.

Analgesic actions of Intrathecal NaV 1.7 antisense in rats: loss of antagonist channel binding, message depletion, and neuraxial distribution of oligonucleotide

This study evaluates the analgesic effects of intrathecal NaV 1.7 antisense oligonucleotides in rats, showing reduced channel binding and pain behaviors with concentration-dependent knock-down of Scn9a mRNA.

D-Serine inhibits non-ionotropic NMDA receptor signaling

This study shows that D-serine inhibits non-ionotropic NMDA receptor signaling and plasticity by blocking glutamate-induced conformational changes in the absence of co-agonist.

SYNPLA: A synapse-specific method for identifying learning-induced synaptic plasticity loci

SYNPLA identifies learning-induced synaptic plasticity loci by detecting circuit-specific changes in synaptic strength.