Tony L. Yaksh

This study shows that TLR-4 enhances TRPV1-mediated calcium influx in DRG neurons through PKA signaling, contributing to pain hypersensitivity.

This study introduces Adaptive Charge Modulation (ACM) for spinal cord stimulation, achieving focal activation at deep tissue sites with reduced surface activation and muscle co-activation.

The paper develops a human-derived in vitro model of nociceptive signaling using HD10.6 cells to study pain mechanisms and drug responses.

This study identifies SEMA4D and OSM as mediators of neutrophil-neuron communication in arthritis-induced pain, showing their role in neuronal sprouting and hypersensitivity.

This study evaluates the analgesic effects of intrathecal NaV 1.7 antisense oligonucleotides in rats, showing reduced channel binding and pain behaviors with concentration-dependent knock-down of Scn9a mRNA.

The paper identifies novel synaptic pathways from the periaqueductal gray and rostroventral medulla to the locus coeruleus that drive opioid-mediated antinociception.

This study shows that 12/15-Lipoxygenases contribute to neuropathic-like pain hypersensitivity in female mice, with inhibitors reversing pain symptoms.

This study develops a method to achieve long-lasting, non-addictive pain relief by epigenetically repressing NaV1.7 in vivo using CRISPR-dCas9 and zinc finger proteins.