MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis
Patrick A. Carroll, Pei Feng Cheng, Brian W. Freie, Sivakanthan Kasinathan, Haiwei Gu, Theresa Hedrich, James A. Dowdle, Vivek Venkataramani, Vijay Ramani, Daniel Raftery, Jay Shendure, Donald E. Ayer, CHARLES H. MULLER, Robert N. Eisenman
This paper shows MLX and MondoA are essential for male fertility and tumor survival, with MLX regulating metabolism, stress, and germ cell development.
bioRxiv · Dec 23, 2020 · PreprintDevelopmental Biology