Brian W. Freie

This paper shows MondoA is essential for MYC-driven pancreatic cancer survival by coordinating MYC network activity with the integrated stress response, and small-molecule inhibition of MondoA kills cancer cells.

This study shows that MAX inactivation disrupts the MYC network, leading to neuroendocrine tumors in multiple tissues by altering transcription factor balance.

This paper shows MLX and MondoA are essential for male fertility and tumor survival, with MLX regulating metabolism, stress, and germ cell development.