Sivakanthan Kasinathan

The paper identifies cis-regulatory elements and transcription factors controlling FOXP3 expression in human Tregs and Tconvs, revealing mechanisms that restrict FOXP3 to Tregs in mice.

SMRT-Tag enables low-input, single-molecule sequencing for simultaneous detection of genetic and epigenetic variations in human samples.

This study uses a single-molecule platform to show that SNF2h, a chromatin remodeler, regulates DNA accessibility based on nucleosome density in vitro and in vivo.

This paper shows MLX and MondoA are essential for male fertility and tumor survival, with MLX regulating metabolism, stress, and germ cell development.

The paper introduces a single-molecule sequencing method to measure nucleosome positions on chromatin fibers and reveals heterogeneous patterns of oligonucleosome occupancy across epigenomic domains.