Colitis-induced visceral pain recruits central neurotensin neurons that modulate colonic sensitivity
Yu-Ting Cheng, Natalie MacKinnon-Booth, Yingfu Jiao, Jordan R Robbins, Murillo Duarte-Silva, Perry E. Mitchell, Yuchu Liu, Omer Barkai, Keunjung Heo, Biyao Zhang, Bruna Lenfers Turnes, Meenakshi Rao, Clifford J. Woolf
This study identifies neurotensin-expressing neurons in the parabrachial nucleus that modulate colonic sensitivity and pain in colitis, suggesting neurotensin as a therapeutic target.
bioRxiv · Mar 2, 2026 · PreprintNeuroscience