Biyao Zhang

This study develops a TECPR2 knock-in mouse model and shows that AAV9-mediated gene therapy improves mechanosensory function, gait, and startle responses in neonatal mice with TECPR2 deficiency.

This study identifies neurotensin-expressing neurons in the parabrachial nucleus that modulate colonic sensitivity and pain in colitis, suggesting neurotensin as a therapeutic target.

ARBEL automatically classifies 3D pain behaviors in mice using light-based analysis and pose estimation, achieving high precision and enabling efficient drug screening.

This study demonstrates the use of lipid nanoparticles to deliver siRNA to dorsal root ganglion neurons, effectively silencing TRPV1 and reducing pain-related behaviors.