A model of inborn metabolism errors associated with adenine amyloid-like fiber formation reduces TDP-43 aggregation and toxicity in yeast
Sangeun Park, Sei-Kyoung Park, Peter Blair, Susan Weiss Liebman
The paper investigates how a yeast model of inborn metabolism errors affects TDP-43 aggregation and toxicity, finding that it shifts aggregates toward an amyloid-like state while reducing toxicity.
Microbial Cell · May 22, 2025Peer-reviewedGenetics