Deletion of the Saccharomyces cerevisiae RACK1 homolog, ASC1, enhances autophagy and counteracts TDP-43 toxicity
Sei-Kyoung Park, Sangeun Park, Susan Weiss Liebman
This paper shows that deleting ASC1 in yeast reduces TDP-43 toxicity by enhancing autophagy, rather than through polysome sequestration, while FUS toxicity remains unaffected.
Genetics · Jan 19, 2026Peer-reviewedCell Biology