A timed epigenetic switch balances T and ILC lineage proportions in the thymus
Nicholas A. Pease, Kathryn M. Denecke, Lihua Chen, Peter Habib Gerges, Hao Yuan Kueh
The paper shows that delaying Bcl11b activation via an epigenetic switch increases ILC generation and reduces T cell output in the thymus by redirecting progenitors at the T/ILC branchpoint.
Development · Dec 1, 2024Peer-reviewedDevelopmental Biology