Hao Yuan Kueh

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

This paper describes a designed IL-21 mimic, 21h10, which shows potent antitumor activity in multiple models and reduces toxicity through TNF blockade.

This paper shows that T-cell receptor signaling uses condensate nucleation to selectively detect single foreign peptides by amplifying weak signals and setting spatial-temporal thresholds.

The paper shows that delaying Bcl11b activation via an epigenetic switch increases ILC generation and reduces T cell output in the thymus by redirecting progenitors at the T/ILC branchpoint.

This paper introduces UPSIDE, a deep learning platform that identifies dynamic cell phenotypic states from transmitted light movies by clustering latent representations and inferring transition rates.

The paper introduces SCEPTRE, a method combining expansion microscopy with histone modification analysis to study chromatin states in single cells at high resolution.

The paper identifies an epigenetic timer mechanism that controls temporal scaling in developmental gene networks, enabling flexible size control through delayed activation of key regulators.

The paper shows that stochastic cis-acting events at the Bcl11b locus control T-cell lineage commitment dynamics through a delay in gene activation.