HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence
Konstantinos Sofiadis, Miloš Nikolić, Yulia Kargapolova, Nataša Josipović, Anne Zirkel, Antonis Papadakis, Ioanna Papadionysiou, Gary Loughran, James Keanes, Audrey Michel, Eduardo Gade Gusmao, Athanasia Mizi, Theodore Georgomanolis, Janine Altmüller, Peter Nürnberg, , Argyris Papantonis
This study identifies HMGB1 as an RNA-binding protein that coordinates chromatin folding and RNA homeostasis in senescence through interactions with other RBPs and regulation of SASP-related transcripts.
Molecular Systems Biology · Jun 1, 2021Peer-reviewedGenomics