Konstantinos Sofiadis

Senescent cells cluster CTCF on nuclear speckles to sustain their splicing program

This paper identifies senescence-induced CTCF clusters (SICCs) and shows they sustain the senescence splicing program by repurposing nuclear speckle components.

Variant U1 snRNAs contribute to cell cycle and differentiation control of human iPS cells

This study shows that variant U1 snRNAs affect gene expression and cell cycle in human iPS cells through alternative splicing changes.

Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor

This study uses a small molecule inhibitor to rapidly and synchronously induce senescence-like features in human cells, enabling analysis of its core regulatory program without paracrine effects.

A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

The paper identifies causal SNPs near ERAP2 that regulate its expression through long-range chromatin interactions, linking autoimmune disease risk variants to enhancer activity.

Aging-associated changes in transcriptional elongation influence metazoan longevity.

This study identifies aging-associated increases in transcriptional elongation speed across multiple species and shows that reducing this speed extends lifespan.

Building regulatory landscapes: enhancer recruits cohesin to create contact domains, engage CTCF sites and activate distant genes

This study shows enhancers recruit cohesin to form chromatin domains, engage CTCF sites, and activate distant genes, with transcription factors and mediator required for all distances but cohesin specifically for long-range activation.

HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence

This study identifies HMGB1 as an RNA-binding protein that coordinates chromatin folding and RNA homeostasis in senescence through interactions with other RBPs and regulation of SASP-related transcripts.

Topological Demarcation By HMGB2 Is Disrupted Early Upon Senescence Entry Across Cell Types And Induces CTCF Clustering

The paper identifies HMGB2 loss as an early event in senescence that disrupts chromatin organization by inducing CTCF clustering across multiple human cell types.